Our Consortium Publications

The NDC is dedicated to funding innovative foundational basic science.

Here are selected key publications that highlight the NDC’s impact:

TSAI LAB

Reconstruction of the human blood-brain barrier in vivo reveals a pathogenic mechanism of APOE4 in pericytes.

Blanchard JW, Bula M, Davila-Velderrain J, Akay LA, Zhu L, Frank A, Victor MB, Bonner JM, Mathys H, Lin Y-T, Ko T, Bennet DA, Cam HP, Kellis M, Tsai L-H. Nature Med. 2020 Jun;26(6):952-963. doi: 10.1038/s41591-020-0886-4. Epub 2020 Jun 8.

PICALM rescues endocytic defects caused by the Alzheimer’s disease risk factor APOE4.

Narayan P, Sienski G, Bonner JM, Lin Y-T, Seo J, Baru V, Haque A, Milo B, Akay L, Graziosi A, Freyzon Y, Landgraf D, Hesse WR, Valastyan J, Immaculada Barrasa M, Tsai L-H*, Linquist S. Cell Rep. 2020 Oct 6;33(1):108224. doi: 10.1016/j.celrep.2020.108224. *Corresponding author

Phosphoproteomics identifies microglial Siglec‐F inflammatory response during neurodegeneration.

Morshed N, Ralvenius WT, Nott A, Watson LA, Rodriguez FH, Akay LA, Joughin BA, Pao P-C, Penney J, LaRocque L, Mastroeni D, Tsai L-H, White FM. Mol Syst Biol. 2020 16: e9819. PMID: 33289969. doi: 10.15252/msb.20209819.

APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia.

Sienski G, Narayan P, Bonner JM, Kory N, Boland S, Arczewska A, Ralvenius WT, Akay L, Lockshin E, He L, Milo B, Graziosi A, Baru V, Lewis CA, Kellis M, Sabatini D, Tsai L-H. Sci Transl Med. 2021 Mar 3;13(583):eaaz4564. doi: 10.1126/scitranslmed.aaz4564. PMID: 33658354.

APOE-4-carrying human astrocytes oversupply cholesterol to promote neuronal lipid raft expansion and Ab generation.

Lee SI, Jeong W, Lim H, Cho S, Lee H, Jang Y, Cho J, Bae S, Lin Y-T, Tsai L-H, Moon DW, Seo J. Stem Cell Reports 2021 Aug 7:S2213-6711(21)00383-0. doi: 10.1016/j.stemcr.2021.07.017. E-published Aug 26

Modeling Alzheimer’s disease with iPSC-derived brain cells.

Penney J, Ralvenius WT & Tsai, L-H. Mol Psychiatry. 2020 Jan;25(1):148-167. Epub 2019 Aug 7. doi: 10.1038/s41380-019-0468-3. PMID: 31391546.

Dissecting the complexities of Alzheimer’s disease with in vitro models of the human brain.

Blanchard JW, Victor MB, Tsai L-H. Nat Rev Neurol. 2021. doi: 10.1038/s41582-021-00578-6. E-pub Nov 8.

GOATE/MARCORA/SHAEFER LABS

Alzheimer's-associated PU.1 expression levels regulate microglial inflammatory response.

Pimenova AA, Herbinet M, Gupta I, Machlovi SI, Bowles KR, Marcora E, Goate AM. Neurobiology of Disease. 105217. PMID 33301878 DOI: 10.1016/j.nbd.2020.105217

Integration of Alzheimer's disease genetics and myeloid genomics identifies disease risk regulatory elements and genes.

Novikova G, Kapoor M, Tcw J, Abud EM, Efthymiou AG, Chen SX, Cheng H, Fullard JF, Bendl J, Liu Y, Roussos P, Björkegren JL, Liu Y, Poon WW, Hao K, ... Marcora E, et al. Nature Communications. 12: 1610. PMID 33712570 DOI: 10.1038/s41467-021-21823-y

Beyond association: successes and challenges in linking non-coding genetic variation to functional consequences that modulate Alzheimer's disease risk.

Novikova G, Andrews SJ, Renton AE, Marcora E. Molecular Neurodegeneration. 16: 27. PMID 33882988 DOI: 10.1186/s13024-021-00449-0

LIDDELOW LAB

Neurotoxic reactive astrocytes induce cell death via saturated lipids.

Guttenplan KA, Weigel MK*, Prakash P*, Wijewardhane PR, Hasel P, Rufen-Blanchette U, Münch AE, Blum JA, Fine J, Neal MC, Bruce KD, Gitler AD, Chopra G, Liddelow SA#, Barres BA# (2021) Nature 599:102–107. PMID: 34616039.

Neuroinflammatory astrocyte subtypes in the mouse brain.

Hasel P, Rose IVL, Sadick JS, Kim RD, Liddelow SA (2021) Nat Neurosci 24:1475-1487. PMID: 34413515.

Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model.

Guttenplan KA, Weigel MK, Adler DI, Couthouis J, Liddelow SA*, Gitler AD*, Barres BA* (2020) •Nat Commun 11:3753. PMID: 32719333.

Early stage differentiation of glia in human and mouse.

Frazel P, Labib D, Brosh R, Boeke JD, Fossati V, Liddelow SA.bioRxiv 2021.12.07.471509 [Preprint] December 9, 2021.

Melanoma-secreted amyloid beta suppresses neuroinflammation and promotes brain metastasis.

Kleffman K, Levinson G, Rose IVL, Blumenberg LM, Shadaloey SAA, Dhabaria A, Wong E, Galan-Echevarria F, Karz A, Argibay D, Von Itter R, Floristan A, Baptiste G, Eskow NM, Tranos JA, Chen J, Vega Y Saenz de Miera EC, Call M, Rogers R, Jour G, Wadghiri YZ, Osman I, Li YM, Mathews P, DeMattos R, Ueberheide B, Ruggles KV, Liddelow SA, Schneider RJ, Hernando E. Cancer Discov. 2022; 12(5):1314-1335. PMID: 35262173.

INPP5D limits plaque formation and glial reactivity in the APP/PS1 mouse model of Alzheimer's disease.

Castranio EL*, Hasel P*, Haure-Mirange J-V, Ramirez AV, Hamilton BW, Kim RD, Wang M, Zhang B, Gandy S, Liddelow SA#, Ehrlich ME#. bioRxiv 2022.04.29.490076 Accepted at Alzheimer’s & Dementia.

Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation.

Fernández-Castañeda A, Lu P, Geraghty AC, Song E, Lee MH, Wood J, O'Dea MR, Dutton S, Shamardani K, Nwangwu K, Mancusi R, Yalçın B, Taylor KR, Acosta-Alvarez L, Malacon K, Keough MB, Ni L, Woo PJ, Contreras-Esquivel D, Toland AMS, Gehlhausen JR, Klein J, Takahashi T, Silva J, Israelow B, Lucas C, Mao T, Peña-Hernández MA, Tabachnikova A, Homer RJ, Tabacof L, Tosto-Mancuso J, Breyman E, Kontorovich A, McCarthy D, Quezado M, Vogel H, Hefti MM, Perl DP, Liddelow S, Folkerth R, Putrino D, Nath A, Iwasaki A, Monje M. Cell. 2022; 185(14):2452-2468. PMID: 35768006.

Astrocytes and oligodendrocytes undergo subtype-specific transcriptional changes in Alzheimer's disease.

Sadick JS*, O'Dea MR*, Hasel P, Dykstra T, Faustin A, Liddelow SA. Neuron. 2022; 110(11):1788-1805. PMID: 35381189.

FROST LAB

Pathogenic tau accelerates aging-associated activation of transposable elements in the mouse central nervous system.

Ramirez P, Sun W, Zuniga G, Ochoa E, DeVos S, Hyman B, Chiu G, Roy ER, Orr M, Buggia-Prevot V, Ray WJ, Frost B (2022) Progress in Neurobiology, 208:102181.

CHIN LAB

TRPM4 conductances in thalamic reticular nucleus neurons generate persistent firing during slow oscillations.

O'Malley JJ, Seibt F, Chin J, Beierlein M (2020) Journal of Neuroscience 40(25):4813-4823. [PMID: 32414784]

Restoring activity in the thalamic reticular nucleus improves sleep architecture and reduces Abeta accumulation in mice.

Jagirdar R, Fu CH, Park J, Corbett B, Seibt FM, Beierlein M, Chin J (2021) Science Translational Medicine 13:618. DOI: 10.1126/scitranslmed.abh4284

RAY LAB

Inhibition of dual leucine zipper kinase prevents chemotherapy-induced peripheral neuropathy and cognitive impairments.

Ma J, Goodwani S, Acton PJ, Buggia-Prevot V, Kesler SR, Jamal I, Mahant ID, Liu Z, Mseeh F, Roth BL, Chakraborty C, Peng B, Wu Q, Jiang Y, Le K, Soth MJ, Jones P, Kavelaars A, Ray WJ, Heijnen CJ. Pain. 2021 Oct 1;162(10):2599-2612. doi: 10.1097/j.pain.0000000000002256. PMID: 33872235; PMCID: PMC8442742.

Novel Targets for Alzheimer's Disease: A View Beyond Amyloid.

Ray WJ, Buggia-Prevot V. Annu Rev Med. 2021 Jan 27;72:15-28. doi: 10.1146/annurev-med-052919-120219. Epub 2020 Aug 31. PMID: 32867590.

The Role of APOE4 in Disrupting the Homeostatic Functions of Astrocytes and Microglia in Aging and Alzheimer's Disease.

Fernandez CG, Hamby ME, McReynolds ML, Ray WJ. Front Aging Neurosci. 2019 Feb 11;11:14. doi: 10.3389/fnagi.2019.00014. PMID: 30804776; PMCID: PMC6378415.